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Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.
Gene Name: | cell division cycle 40 |
Synonyms: | CDC40, Cell division cycle 40 homolog, EH-binding protein 3, EHB3, Pre-mRNA splicing factor 17, Pre-mRNA-processing factor 17, PRPF17, HPRP17, PRP17, PRP17 homolog |
Target Sequences: | NM_015891 NP_056975.1 O60508 |
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