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CDC37 is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
Gene Name: | cell division cycle 37 |
Synonyms: | CDC37, Hsp90 co-chaperone Cdc37, CDC37A, p50CDC37 |
Target Sequences: | NM_007065 NP_008996.1 Q16543 |
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