CDC34

cell division cycle 34

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

CDC34 (6)

Publications

No (6)

Tag

6His, N-terminus (1)

GST (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human CDC34 Protein (Recombinant GST) (Full Length) - LS-G27849

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

53.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CDC34 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67279

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.6 kDa

Price:

20 µg/$1,107

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Human CDC34 Protein (Recombinant 6His, N-terminus) (Ala2-Ser236) - LS-G26527

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

28.9 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human CDC34 Protein (Recombinant His) - LS-G934

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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CDC34 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116702

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.6 kDa

Price:

100 µg/$494

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Human CDC34 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79462

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.6 kDa

Price:

20 µg/$150

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