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Cdc14 / CDC14A

cell division cycle 14A

CDC14A, a homolog of the essential Saccharomyces cerevisiae cdc14 gene, is a member of the CDC14 subfamily. The gene product has been shown to dephosphorylate human Cdh1 and activate APC(Cdh1), the anaphase-promoting complex that ubiquitinates mitotic cyclins and allows cells to exit from mitosis. CDC14A also has been shown to interact with interphase centrosomes and to regulate the centrosome duplication cycle. At least three mRNA variants of CDC14A have been identified. Dispruption of centrosome duplication by overexpression or downregulation of CDC14 has been shown to cause aberrant chromosome partitioning into daughter cells leading to genomic instability in mammalian cells. The CDC14A protein has been reported to interact with the tumor suppressor protein p53 both in vitro and in vivo and may regulate the function of p53. CDC14A has been mapped to chromosome band 1p21, a region that has been shown to exhibit loss of heterozygosity in highly differentiated breast carcinoma and malignant mesothelioma. Further, a 48-bp in-frame deletion in the cDNA of the breast carcinoma cell line has been identified, and loss of expression of the wild type allele in this cell line supports the possibility that CDC14A may be a tumor suppressor gene that is targeted for inactivation during tumorigenesis.

Gene Name: cell division cycle 14A
Family/Subfamily: Protein Phosphatase , CDC14
Synonyms: CDC14A, Cdc14A1, Cdc14A2, Cdc14, Cell division cycle 14a, HCDC14, HCDC14a
Target Sequences: NM_003672 NP_003663.2 Q9UNH5

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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
Cdc14 / CDC14A (6)
No (6)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (4)
Human (4)
293T Cells (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
Cdc14 / CDC14A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
69.4 kDa
100 µg/$710
Cdc14 / CDC14A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
66.4 kDa
100 µg/$710
Cdc14 / CDC14A Protein - 12.5% SDS-PAGE of human CDC14A stained with Coomassie Blue
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Wheat Germ Extract
GST
90.97 kDa
2 µg/$439
Cdc14 / CDC14A Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Cdc14 / CDC14A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
66.4 kDa
20 µg/$215
Cdc14 / CDC14A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
69.4 kDa
20 µg/$215
Viewing 1-6 of 6 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).