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CD80

CD80 molecule

Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

Gene Name: CD80 molecule
Synonyms: CD80, Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CD80 antigen, LAB7, CD80 molecule, CTLA-4 counter-receptor B7.1
Target Sequences: NM_005191 NP_005182.1 P33681

Publications (3)

1
Self-reactive human CD4 T cell clones form unusual immunological synapses. Schubert DA, Gordo S, Sabatino JJ, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW. The Journal of experimental medicine. 2012 209:335-52. [PubMed:22312112] [PMC:PMC3280872] Related Antibodies: LS-C40976.
2
Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa. Mrinal K Sarkar, Grace A Hile, Lam C Tsoi, Xianying Xing, Jianhua Liu, Yun Liang, Celine C Berthier, William R Swindell, Matthew T Patrick, Shuai Shao, Pei-Suen Tsou, Ranjitha Uppala, Maria A Beamer, Anshika Srivastava, Stephanie L Bielas, Paul W Harms, Spiro Getsios, James T Elder, John J Voorhees, Johann E Gudjonsson , J Michelle Kahlenberg. Annals of the rheumatic diseases. 2018 Nov;77:1653-1664. [Full Text Article] [PubMed:30021804] [PMC:PMC6185784] Related Antibodies: LS-C115529.
3
Leishmania major infection activates NF-kappaB and interferon regulatory factors 1 and 8 in human dendritic cells. Jayakumar A, Donovan MJ, Tripathi V, Ramalho-Ortigao M, McDowell MA. Infection and immunity. 2008 76:2138-48. [PubMed:18316378] [PMC:PMC2346706] Related Antibodies: LS-C40976.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).