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CD79B / CD79 Beta

CD79b molecule, immunoglobulin-associated beta

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Gene Name:	CD79b molecule, immunoglobulin-associated beta
Synonyms:	CD79B, AGM6, B29, Ig-beta, IGB, CD79b antigen
Target Sequences:	NM_021602 NP_000617.1 P40259

Publications (2)

Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A. Verma-Gaur J, Hauser J, Grundström T. Journal of immunology (Baltimore, Md. : 1950). 2012 188:6175-83. (WB; Mouse) [Full Text Article] [PubMed:22581853] Related Antibodies: LS-C43941.

Broad feedback inhibition of pre-B-cell receptor signaling components. Hauser J, Verma-Gaur J, Grundstr[Character f6]m T. Molecular immunology. 2013 Jul;54:247-53. [Full Text Article] [PubMed:23318223] Related Antibodies: LS-C43941.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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