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CD53

CD53 molecule

CD53 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene Name: CD53 molecule
Family/Subfamily: Tetraspan , not assigned-Tetraspan
Synonyms: CD53, CD53 antigen, CD53 molecule, CD53 tetraspan antigen, Cell surface antigen, Leukocyte surface antigen CD53, Transmembrane glycoprotein, Tetraspanin-25, Tspan-25, CD53 glycoprotein, Cell surface glycoprotein CD53, MOX44, TSPAN25
Target Sequences: NM_000560 NP_000551.1 P19397

Publications (1)

1
The tetraspanin web revisited by super-resolution microscopy. Zuidscherwoude M, Göttfert F, Dunlock VM, Figdor CG, van den Bogaart G, van Spriel AB. Scientific reports. 2015 5:12201. (ICC; Human) [Full Text Article] [PubMed:26183063] [PMC:PMC4505338]

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CD53 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
24.2 kDa
100 µg/$494
CD53 Protein - 12.5% SDS-PAGE of human CD53 stained with Coomassie Blue
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Wheat Germ Extract
GST
50.7 kDa
2 µg/$439
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
10.6 kDa
100 µg/$843
CD53 Protein - Purified recombinant protein CD53 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
24.2 kDa
20 µg/$1,107
CD53 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
24.2 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).