CD46

CD46 molecule, complement regulatory protein

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

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Products

Proteins (13)

Type

Over-Expression Lysate (2)

Recombinant (11)

Target

CD46 (13)

Application

SDS-PAGE (1)

Publications

No (13)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (3)

His,C-terminus (1)

His-GST (2)

Myc-DDK (Flag) (2)

Species

Guinea pig (1)

Human (8)

Mouse (2)

Rat (1)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (2)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (3)

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Human CD46 Protein (Recombinant His,C-terminus) (Met1-Asp328) - LS-G47219

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human CD46 consists of 305 amino acids and has a predicted molecular mass of 34 kDa. As a result of glycosylation, the apparent molecular mass of rh CD46 is approximately 55-60 kDa in SDS-PAGE under reducing conditions.

Price:

50 µg/$410; 500 µg/$1,745

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Mouse CD46 Protein (Recombinant His-GST) (aa157-365) - LS-G13590

Source:

E. coli

Tag:

His-GST

Molecular Weight:

55.2 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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CD46 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105448

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.4 kDa

Price:

100 µg/$494

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Mouse CD46 Protein (Recombinant His) (aa45-329) - LS-G20579

Source:

E. coli

Tag:

His

Molecular Weight:

36 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Rat CD46 Protein (Recombinant His-GST) (aa136-341) - LS-G13593

Source:

E. coli

Tag:

His-GST

Molecular Weight:

54.4 kDa

Price:

10 µg/$285; 50 µg/$465; 100 µg/$742; 200 µg/$930; 1 mg/$2,052; 500 µg/$1,586; 5 mg/$3,249; 2 mg/$2,241

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Human CD46 Protein (Recombinant GST) (Full Length) - LS-G29294

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CD46 Protein (Recombinant His) - LS-G2255

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Guinea pig CD46 Protein (Recombinant 6His, N-terminus) (aa36-316) - LS-G57408

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Human CD46 Protein (Recombinant GST, N-terminus) (aa36-135) - LS-G59203

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CD46 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81353

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.4 kDa

Price:

20 µg/$150

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Human CD46 Protein (Recombinant 6His, C-terminus) (Cys35-Asp328) - LS-G139535

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

33.8 kDa

Price:

10 µg/$288; 50 µg/$436

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Human CD46 Protein (Recombinant 6His, C-terminus) (Cys35-Asp328) - LS-G38849

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

33.83kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human CD46 Protein (Recombinant His) (aa147-285) - LS-G13595

Source:

E. coli

Tag:

His

Molecular Weight:

16.9 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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