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CD4

CD4 molecule

CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Gene Name: CD4 molecule
Synonyms: CD4, CD4 antigen, CD4 receptor, CD4mut, CD4 antigen (p55), CD4 molecule
Target Sequences: NM_000616 NP_000607.1 P01730

Publications (10)

1
Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN. Zenaro E, Donini M, Dusi S. Journal of leukocyte biology. 2009 86:1393-401. [PubMed:19773555]
2
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89. [PubMed:19849846] [PMC:PMC2770477] Related Antibodies: LS-C41126.
3
Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. Cicin-Sain L, Smyk-Pearson S, Smyk-Paerson S, Currier N, Byrd L, Koudelka C, Robinson T, Swarbrick G, Tackitt S, Legasse A, Fischer M, Nikolich-Zugich D, Park B, Hobbs T, Doane CJ, Mori M, Axthelm MK, Axthelm MT, Lewinsohn DA, Nikolich-Zugich J. Journal of immunology (Baltimore, Md. : 1950). 2010 184:6739-45. [PubMed:20483749] [PMC:PMC3504654] Related Antibodies: LS-C41126.
4
Survival of skin graft between transgenic cloned dogs and non-transgenic cloned dogs. Kim GA, Oh HJ, Kim MJ, Jo YK, Choi J, Park JE, Park EJ, Lim SH, Yoon BI, Kang SK, Jang G, Lee BC. PloS one. 2014 9:e108330. (IP; Dog) [Full Text Article] [PubMed:25372489] [PMC:PMC4220905] Related Antibodies: LS-C122857.
5
Acute BVDV-2 infection in beef calves delays humoral responses to a non-infectious antigen challenge. UCVM Class of, McCorkell R, Horsman SR, Wynne-Edwards K, Muench G, van Drunen Littel-van den Hurk S, Waeckerlin R, Eschbaumer M, Dardari R, Chaiyakul M, Gajda P, Czub M, van der Meer F. The Canadian veterinary journal = La revue veterinaire canadienne. 2015 56:1075-83. (IP; Bovine) [PubMed:26483584] [PMC:PMC4572827]
6
Conformational Engineering of HIV-1 Env Based on Mutational Tolerance in the CD4 and PG16 Bound States. Jeremiah D Heredia, Jihye Park, Hannah Choi, Kevin S Gill, Erik Procko. Journal of virology. 2019 June;93: [Full Text Article] [PubMed:30894475] [PMC:PMC6532070] Related Antibodies: LS-C134227.
7
Crucial role of OX40/OX40L signaling in a murine model of asthma. Wei Lei, Daxiong Zeng, Gaoqin Liu, Yehan Zhu, Jiajia Wang, Hongya Wu, Junhong Jiang, Jianan Huang. Molecular medicine reports. 2018 Mar;17:4213-4220. [Full Text Article] [PubMed:29344664] [PMC:PMC5802192] Related Antibodies: LS-C62734.
8
Correlation between innate and adaptive immunity response in TB children post BCG vaccination. Is it effective or not?: Cross-sectional study. Rahmini Shabariah, Farsida, Mochammad Hatta, Ilhamjaya Patellongi, Irfan Idris, Arif Santoso, Andi Asadul Islam, Rosdiana Natzir, Bob Wahyudin, Warsinggih, Sanjoyo. Annals of medicine and surgery (2012). 2022 May;77:103586. [Full Text Article] [PubMed:35638072] [PMC:PMC9142374]
9
Comparison TLR2 and TLR4 serum levels in children with pulmonary and extrapulmonary tuberculosis with and without a Bacillus Calmette-Guérin (BCG) scar. Rahmini Shabariah, Mochammad Hatta, Irfan Idris, Arif Santoso, Ilhamjaya Patellongi, Tria Astika Endah Permatasari, Farsida, Andi Asadul Islam, Rosdiana Natzir, Bob Wahyudin, Warsinggih, Emilda. Journal of clinical tuberculosis and other mycobacterial diseases. 2021 December;25:100272. [Full Text Article] [PubMed:34504953] [PMC:PMC8416952]
10
EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4+CD25+FOXP3+ REGULATORY T CELLS. Weaver KF, Stokes JV, Gunnoe SA, Follows JS, Shafer L, Ammari MG, Archer TM, Thomason JM, Mackin AJ, Pinchuk LM. Journal of veterinary medicine and research. 2014 1: (Flo; Canine) [PubMed:25950023] [PMC:PMC4418640] Related Antibodies: LS-C127352.
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CD4 Mouse anti-Dog Monoclonal Antibody
Dog
Flo, IHC, IHC-Fr, IP
Unconjugated
2 ml/$794
CD4 Antibody - Human peripheral blood lymphocytes stained with purified OKT4, followed by anti-mouse IgGs FITC
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CD4 Mouse anti-Human Monoclonal (OKT4) Antibody
Human, Monkey
Flo, IHC, IHC-Fr
Unconjugated
25 µg/$223; 100 µg/$236
CD4 Antibody - Anti-CD4 antibody IHC staining of human spleen, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Cancer Pathology
Cancer
CD4 Mouse anti-Human Monoclonal (5D9) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CD4 Antibody - Human Spleen, lymphocytes: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
CD4 Mouse anti-Human Monoclonal (7F2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CD4 Antibody - Immunochemical staining of mouse CD4 in mouse colon with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.
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CD4 Rabbit anti-Mouse Monoclonal (Preservative Free) (766) Antibody
Mouse
IHC-P
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
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CD4 Mouse anti-Human Monoclonal (RIV6) Antibody
Mouse, Rat, Human
ELISA, Flo, IF, IHC, IHC-Fr, IP
Unconjugated
100 µg/$567; 1 mg/$1,079
CD4 Antibody - IHC of paraffin-embedded Human tonsil using anti-CD4 mouse monoclonal antibody.
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CD4 Mouse anti-Human Monoclonal (OTI8H3) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$434
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CD4 Mouse anti-Rat Monoclonal (Biotin) (W3/25) Antibody
Rat
Ctox, Flo, IHC, IHC-Fr, IHC-P
Biotin Conjugated
100 µg/$355; 500 µg/$541
CD4 Antibody - Flow cytometry of CD4 antibody This image was taken for the unmodified form of this product. Other forms have not been tested.
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CD4 Mouse anti-Human Monoclonal (Azide-free) (M-T441) Antibody
Human
ELISA, Flo
Unconjugated, Azide-free
100 µg/$411
CD4 Antibody - IHC of CD4 on FFPE Tonsil tissue.
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CD4 Rabbit anti-Human Recombinant Monoclonal (RBT-CD4) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$419
CD4 Antibody - Western blot of recombinant CD4.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD4 Rabbit anti-Mouse Polyclonal (aa27-394) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
CD4 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD4.
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CD4 Mouse anti-Human Monoclonal (OTI10B5) Antibody
Dog, Rat, Human, Monkey
WB
Unconjugated
100 µl/$434
CD4 Antibody - Western blot of CD4 (10H8) mAb at 1:1000 dilution. Lane 1: Jurkat whole cell lysate (30 ug.
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CD4 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$328; 100 µl/$419
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CD4 Mouse anti-Ferret Monoclonal (APC) Antibody
Ferret
Flo
APC Conjugated
25 Tests/$293; 100 Tests/$376
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CD4 Mouse anti-Ferret Monoclonal (FITC) (02) Antibody
Ferret
Flo
FITC Conjugated
25 Tests/$278; 100 Tests/$346
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CD4 Mouse anti-Bovine Monoclonal (FITC) (CC8) Antibody
Bovine
Flo
FITC Conjugated
0.1 mg/$540
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CD4 Mouse anti-Chicken Monoclonal (FITC) (2-35) Antibody
Chicken
Flo
FITC Conjugated
0.1 mg/$540
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CD4 Mouse anti-Rabbit Monoclonal (FITC) (KEN-4) Antibody
Rabbit
Flo
FITC Conjugated
100 Tests/$540
CD4 Antibody
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CD4 Rabbit anti-Rhesus monkey Polyclonal (aa26-396) Antibody
Mouse, Human, Rhesus monkey
WB
Unconjugated
100 µl/$331; 200 µl/$382; 500 µl/$553; 1 ml/$660; 2 ml/$896; 5 ml/$1,499
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CD4 Rat anti-Mouse Monoclonal (FITC) (CT-CD4) Antibody
Mouse
Flo, IHC, IHC-Fr
FITC Conjugated
100 µg/$412; 300 µg/$674
CD4 Antibody - Flow cytometry of CD4 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD4 Mouse anti-Human Monoclonal (FITC) (M-T441) Antibody
Human
ELISA, Flo
FITC Conjugated
120 Tests/$446
CD4 Antibody
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CD4 Mouse anti-Human Monoclonal (Edu-2) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P
Unconjugated
1 ml/$424
CD4 Antibody - IHC of paraffin-embedded Human lymph node tissue using anti-CD4 mouse monoclonal antibody.
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CD4 Mouse anti-Human Monoclonal (OTI2H8) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
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CD4 Rat anti-Mouse Monoclonal (YTS191.1) Antibody
Mouse
Flo, IHC, IHC-Fr
Unconjugated
0.1 mg/$385
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CD4 Mouse anti-Guinea pig Monoclonal (Supernatant) (CT7) Antibody
Guinea pig
Flo, IHC-Fr
Unconjugated, Supernatant
0.25 ml/$516
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).