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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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CD4

CD4 molecule

CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Gene Name: CD4 molecule
Synonyms: CD4, CD4 antigen, CD4 receptor, CD4mut, CD4 antigen (p55), CD4 molecule
Target Sequences: NM_000616 NP_000607.1 P01730

Publications (6)

1
Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN. Zenaro E, Donini M, Dusi S. Journal of leukocyte biology. 2009 86:1393-401. [PubMed:19773555]
2
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89. [PubMed:19849846] [PMC:PMC2770477] Related Antibodies: LS-C41126.
3
Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. Cicin-Sain L, Smyk-Pearson S, Smyk-Paerson S, Currier N, Byrd L, Koudelka C, Robinson T, Swarbrick G, Tackitt S, Legasse A, Fischer M, Nikolich-Zugich D, Park B, Hobbs T, Doane CJ, Mori M, Axthelm MK, Axthelm MT, Lewinsohn DA, Nikolich-Zugich J. Journal of immunology (Baltimore, Md. : 1950). 2010 184:6739-45. [PubMed:20483749] [PMC:PMC3504654] Related Antibodies: LS-C41126.
4
Survival of skin graft between transgenic cloned dogs and non-transgenic cloned dogs. Kim GA, Oh HJ, Kim MJ, Jo YK, Choi J, Park JE, Park EJ, Lim SH, Yoon BI, Kang SK, Jang G, Lee BC. PloS one. 2014 9:e108330. (IP; Dog) [Full Text Article] [PubMed:25372489] [PMC:PMC4220905] Related Antibodies: LS-C122857.
5
Acute BVDV-2 infection in beef calves delays humoral responses to a non-infectious antigen challenge. UCVM Class of, McCorkell R, Horsman SR, Wynne-Edwards K, Muench G, van Drunen Littel-van den Hurk S, Waeckerlin R, Eschbaumer M, Dardari R, Chaiyakul M, Gajda P, Czub M, van der Meer F. The Canadian veterinary journal = La revue veterinaire canadienne. 2015 56:1075-83. (IP; Bovine) [PubMed:26483584] [PMC:PMC4572827]
6
EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4+CD25+FOXP3+ REGULATORY T CELLS. Weaver KF, Stokes JV, Gunnoe SA, Follows JS, Shafer L, Ammari MG, Archer TM, Thomason JM, Mackin AJ, Pinchuk LM. Journal of veterinary medicine and research. 2014 1: (Flo; Canine) [PubMed:25950023] [PMC:PMC4418640] Related Antibodies: LS-C127352.
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☰ Filters
CD4 (601)
No (598)
Yes (3)
Viewing 1-25 of 601 items
CD4 Antibody - Anti-CD4 antibody IHC staining of human spleen, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer
Mouse Monoclonal [clone 5D9] (IgG2a) to Human CD4
Human, Monkey
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
CD4 Antibody - Human Spleen, lymphocytes: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
Mouse Monoclonal [clone 7F2] (IgG2a) to Human CD4
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $425.00
CD4 Antibody - Human peripheral blood lymphocytes stained with purified OKT4, followed by anti-mouse IgGs FITC
Select
(2) Publication(s)
Mouse Monoclonal [clone OKT4] (IgG2b) to Human CD4
Human, Monkey
Flo, IHC, IHC-Fr
Unconjugated
25µg   0.5mg/ml   $165.00; 100µg   0.5mg/ml   $185.00
CD4 Antibody - Immunohistochemistry-Paraffin: CD4 Antibody - Staining of paraffin-embedded mouse brain tissue. Photo courtesy of product review by verified customer.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human CD4
Rabbit, Mouse, Dog, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $335.00
CD4 Antibody - IHC of paraffin-embedded Human tonsil using anti-CD4 mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI8H3] (IgG2b) to Human CD4
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $345.00
Select
Mouse Monoclonal [clone W3/25] (IgG1) to Rat CD4
Rat
Ctox, Flo, IHC, IHC-Fr, IHC-P
Biotin Conjugated
100µg   $265.00; 500µg   0.1mg/ml   $405.00
CD4 Antibody - Flow cytometry of CD4 antibody This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone M-T441] (IgG2b) to Human CD4
Human
ELISA, Flo
Unconjugated, Azide-free
100µg   1mg/ml   $315.00
CD4 Antibody - Western blot of CD4 (10H8) mAb at 1:1000 dilution. Lane 1: Jurkat whole cell lysate (30 ug.
Select
Mouse Monoclonal to Human CD4
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $345.00
CD4 Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with peroxidase-conjugate and DAB chromogen. Note membrane staining of T cells.
Select
Mouse Monoclonal [clone 4B12] (IgG1,k) to Human CD4
Human
IHC, IHC-P
Unconjugated
100µl   $365.00; 500µl   $875.00
CD4 Antibody - IHC of CD4 on FFPE Tonsil tissue.
Select
Rabbit Recombinant Monoclonal [clone RBT-CD4] (IgG) to Human CD4
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1ml   $325.00; 0.5ml   $545.00; 1ml   $830.00
CD4 Antibody - Western blot of recombinant CD4.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse CD4
Mouse
WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $295.00; 1ml   0.5mg/ml   $515.00
CD4 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD4.
Select
Mouse Monoclonal [clone OTI10B5] (IgG1) to Human CD4
Dog, Rat, Human, Monkey
WB
Unconjugated
100µl   1mg/ml   $345.00
Select
Mouse Monoclonal [clone CC8] (IgG2a) to Bovine CD4
Bovine
Flo
FITC Conjugated
0.1mg   $485.00
Select
Mouse Monoclonal [clone 2-35] (IgG2b) to Chicken CD4
Chicken
Flo
FITC Conjugated
0.1mg   $485.00
Select
Mouse Monoclonal [clone KEN-4] (IgG2a) to Rabbit CD4
Rabbit
Flo
FITC Conjugated
100tst   $485.00
CD4 Antibody
Select
Rabbit Polyclonal to Rhesus monkey CD4
Mouse, Human, Rhesus monkey
WB
Unconjugated
20µl   0.5mg/ml   $215.00; 100µl   0.5mg/ml   $285.00; 200µl   0.5mg/ml   $335.00; 1ml   0.5mg/ml   $635.00
Select
(1) Publication(s)
Mouse Monoclonal (IgG1) to Dog CD4
Dog
Flo, IHC, IHC-Fr, IP
Unconjugated
2ml   $665.00
Select
Mouse Monoclonal [clone RIV6] (IgG2a) to Human CD4
Mouse, Rat, Human
ELISA, Flo, IF, IHC, IHC-Fr, IP
Unconjugated
100µg   $485.00
CD4 Antibody - IHC of paraffin-embedded Human lymph node tissue using anti-CD4 mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI2H8] (IgG2a) to Human CD4
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
Select
Rat Monoclonal [clone YTS191.1] (IgG2b) to Mouse CD4
Mouse
Flo, IHC, IHC-Fr
Unconjugated
100µg   1mg/ml   $245.00
CD4 Antibody - Flow cytometry of CD4 antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone M-T441] (IgG2b) to Human CD4
Human
ELISA, Flo
FITC Conjugated
120tst   $345.00
Select
(1) Publication(s)
Rat Monoclonal (IgG2a) to Dog CD4
Dog
Flo
FITC Conjugated
100tst   $890.00
Select
Mouse Monoclonal [clone RFT4] (IgG1) to Human CD4
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
0.1mg   0.1mg/ml   $225.00
CD4 Antibody
Select
Mouse Monoclonal [clone Edu-2] (IgG2a) to Human CD4
Human
Flo, IHC, IHC-Fr, IHC-P
Unconjugated
100µg/ml   $375.00
Select
Mouse Monoclonal [clone 11A1] to Human CD4
Mouse, Rat, Human
IF, IHC
Unconjugated
50µl   $235.00; 100µl   $265.00; 200µl   $335.00

Viewing 1-25 of 601 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).