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CD39

ectonucleoside triphosphate diphosphohydrolase 1

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Gene Name:	ectonucleoside triphosphate diphosphohydrolase 1
Synonyms:	ENTPD1, ATPDase, CD39, CD39 antigen, Ecto-apyrase, Ecto-ATPDase 1, Ecto-ATP diphosphohydrolase 1, Ecto-ATPase 1, NTPDase-1, NTPDase 1
Target Sequences:	NM_001776 NP_001767.3 P49961

Publications (2)

The ENTPD1 promoter polymorphism -860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk. Maloney JP, Branchford BR, Brodsky GL, Cosmic MS, Calabrese DW, Aquilante CL, Maloney KW, Gonzalez JR, Zhang W, Moreau KL, Wiggins KL, Smith NL, Broeckel U, Di Paola J. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017 July;31:2771-2784. [Full Text Article] [PubMed:28302652] [PMC:PMC6137499]

Immune related endonucleases and GTPases are not associated with tumor response in patients with advanced non-small cell lung cancer treated with checkpoint inhibitors. H O Ramdani, M Falk, L C Heukamp, S Schatz, M Tiemann, C Wesseler, L Diehl, E Schuuring, H J M Groen, F Griesinger. Pathology, research and practice. 2021 November;227:153651. [Full Text Article] [PubMed:34673351] Related Antibodies: LS-B13080.

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