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CD38

CD38 molecule

Synthesizes the second messangers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Gene Name:	CD38 molecule
Synonyms:	CD38, ADP-ribosyl cyclase 1, CD38 antigen (p45), CD38 antigen, Cyclic ADP-ribose hydrolase 1, T10, CADPr hydrolase 1, CD38 molecule, NAD(+) nucleosidase
Target Sequences:	NM_001775 NP_001766.2 P28907

Publications (3)

CD38 is methylated in prostate cancer and regulates extracellular NAD. Mottahedeh J, Haffner MC, Grogan TR, Hashimoto T, Crowell PD, Beltran H, Sboner A, Bareja R, Esopi D, Isaacs WB, Yegnasubramanian S, Rettig MB, Elashoff DA, Platz EA, De Marzo AM, Teitell MA, Goldstein AS. Cancer & metabolism. 2018 September;6:13. [Full Text Article] [PubMed:30258629] [PMC:PMC6150989] Related Antibodies: LS-A9696.

SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis. Collin R Diedrich, Tara Rutledge, Pauline Maiello, Tonilynn M Baranowski, Alexander G White, H Jacob Borish, Paul Karell, Forrest Hopkins, Jessica Brown, Sarah M Fortune, JoAnne L Flynn, Zandrea Ambrose, Philana Ling Lin. PLoS pathogens. 2020 July;16:e1008413. [Full Text Article] [PubMed:32730321] [PMC:PMC7419014] Related Antibodies: LS-A9696.

Different Innate Immune Responses in BALB/c and C57BL/6 Strains following Corneal Transplantation. Tim Bleul, Xinyu Zhuang, Antonia Hildebrand, Clemens Lange, Daniel Böhringer, Günther Schlunck, Thomas Reinhard, Thabo Lapp. Journal of innate immunity. 2020 September;44501. [Full Text Article] [PubMed:32906119] [PMC:PMC7879253] Related Antibodies: LS-C43670.

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