Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
|Gene Name:||CD33 molecule|
|Family/Subfamily:||Immunoglobulin , not assigned-Immunoglobulin|
|Synonyms:||CD33, CD33 antigen, CD33 molecule, gp67, SIGLEC-3, p67, CD33 antigen (gp67), SIGLEC3|
|Target Sequences:||NM_001772 NP_001763.3 P20138|
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