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May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Gene Name: | immunoglobulin superfamily, member 8 |
Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
Synonyms: | IGSF8, CD316 antigen, CD81 partner 3, CD81P3, KCT4, LIR-D1, CD316, EWI-2, EWI2, KCT-4, PGRL |
Target Sequences: | NM_052868 NP_443100.1 Q969P0 |
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