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CD244

CD244 molecule, natural killer cell receptor 2B4

CD244 is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name:	CD244 molecule, natural killer cell receptor 2B4
Synonyms:	CD244, 2B4, H2B4, NAIL, NKR2B4, Nmrk, SLAMF4, CD244 antigen
Target Sequences:	NM_016382 NP_057466.1 Q9BZW8

Publications (1)

Simultaneous TCR and CD244 signals induce dynamic downmodulation of CD244 on human antiviral T cells. Pacheco Y, McLean AP, Rohrbach J, Porichis F, Kaufmann DE, Kavanagh DG. Journal of immunology (Baltimore, Md. : 1950). 2013 191:2072-81. (Flo; Human) [Full Text Article] [PubMed:23913963] [PMC:PMC3777852]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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