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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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CD22

CD22 molecule

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Gene Name: CD22 molecule
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: CD22, CD22 molecule, CD22 antigen, SIGLEC2, SIGLEC-2, T-cell surface antigen Leu-14, B-cell receptor CD22, BL-CAM
Target Sequences: NM_001771 NP_001762.2 P20273

Publications (1)

1
Epitope mapping and key amino acid identification of anti-CD22 immunotoxin CAT-8015 using hybrid -lactamase display. Bannister D, Popovic B, Sridharan S, Giannotta F, File P, Yilmaz N, Minter R. Protein engineering, design & selection : PEDS. 2011 24:351-60. (IP) [PubMed:21159620] [PMC:PMC3049344]

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CHO Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
75.0 kDa
5µg   $215.00; 20µg   $285.00
CD22 Protein - Human Siglec-2 / CD22 isoform beta, Human Recombinant
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HEK 293 Cells
His, C-Terminal
Less than 1.0 EU/µg protein.
77 kDa
50µg   $475.00
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293T Cells
Myc + DDK
95.8 kDa
20µg   $195.00
CD22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc + DDK
76.2 kDa
20µg   $195.00
CD22 Protein - Purified recombinant protein CD22 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc + DDK
95.2 kDa
20µg   $890.00
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None
76.5 kDa
300µg   $305.00
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None
102 kDa
300µg   $305.00
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None
76.7 kDa
300µg   $305.00
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None
102.1 KDa (SDS-PAGE)
300µg   $305.00
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None
104.3 kDa (SDS-PAGE)
300µg   $305.00
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None
78.8 kDa (SDS-PAGE)
300µg   $305.00
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None
76.6 kDa (SDS-PAGE)
300µg   $305.00
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None
101.9 kDa
300µg   $305.00
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None
58.5 kDa (SDS-PAGE)
300µg   $305.00
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
78.8 kDa
50µg   $485.00; 100µg   $815.00
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Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
104.3 kDa
50µg   $485.00; 100µg   $815.00
CD22 Protein - Recombinant Sialic Acid Binding Ig Like Lectin 2 By SDS-PAGE
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E. coli
His
26.7 kDa
10µg   $295.00; 50µg   $485.00; 100µg   $665.00; 200µg   $980.00; 1mg   $2,520.00; 500µg   $1,110.00
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CHO Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
~75 kDa
50µg   $1,095.00; 10µg   $325.00
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
76.6 kDa
50µg   $545.00; 100µg   $815.00
CD22 Protein
Select
CHO Cells
None
Less than 1 ng/µg of protein (determined by LAL method).
75 kDa
20µg   $345.00
CD22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc + DDK
76.2 kDa
100µg   $485.00
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Sf9 Cells
hIgG-His-tag, C-terminus
102.1kDa
1µg   $195.00; 5µg   $255.00; 50µg   $1,260.00
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Mammalian Cells
Fc,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
102.3 kDa
10µg   $265.00; 50µg   $425.00
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Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
76.2 kDa
10µg   $265.00; 50µg   $425.00
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HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
58.5 kDa
50µg   $425.00; 100µg   $605.00

Viewing 1-25 of 26 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).