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CD207 / Langerin

CD207 molecule, langerin

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.

Gene Name: CD207 molecule, langerin
Synonyms: CD207, CD207 antigen, langerin, CD207 antigen, CD207 molecule, langerin, CLEC4K, Langerin
Target Sequences: NM_015717 NP_056532.4 Q9UJ71

Publications (1)

1
Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-ß1. Hahn JM, McFarland KL, Combs KA, Supp DM. Burns & trauma. 2016 4:30. (IHC; Human) [Full Text Article] [PubMed:27574697] [PMC:PMC4994224] Related Antibodies: LS-C312086.

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
CD207 / Langerin (8)
No (8)
6His, N-terminus (2)
GST (1)
His (1)
His,N-terminus (1)
Myc-DDK (Flag) (2)
Myc-DDK (Flag), C-terminus (1)
Human (6)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Human (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (2)
CD207 / Langerin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
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Human
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
31.5kD
50 µg/$395; 500 µg/$1,585; 1 mg/$2,157; 10 µg/$281
CD207 / Langerin Protein - Purified recombinant protein CD207 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag), C-terminus
36.5 kDa
20 µg/$1,107
CD207 / Langerin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
36.5 kDa
100 µg/$494
CD207 / Langerin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
36.5 kDa
20 µg/$150
CD207 / Langerin Protein - 12.5% SDS-PAGE of human CD207 stained with Coomassie Blue
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Wheat Germ Extract
GST
61.82 kDa
10 µg/$479; 25 µg/$670
CD207 / Langerin Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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Mammalian Cells
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
31.5 kDa
10 µg/$281; 50 µg/$389
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).