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CD207 / Langerin

CD207 molecule, langerin

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.

Gene Name: CD207 molecule, langerin
Synonyms: CD207, CD207 antigen, langerin, CD207 antigen, CD207 molecule, langerin, CLEC4K, Langerin
Target Sequences: NM_015717 NP_056532.4 Q9UJ71

Publications (1)

1
Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-ß1. Hahn JM, McFarland KL, Combs KA, Supp DM. Burns & trauma. 2016 4:30. (IHC; Human) [Full Text Article] [PubMed:27574697] [PMC:PMC4994224] Related Antibodies: LS-C312086.

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CD207 / Langerin ELISA Kit
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0.102 - 25 ng/ml
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).