Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
CD200, also known as OX-2, is a type I membrane protein belonging to the Ig superfamily. It has a 202 amino acid extracellular domain and a short cytoplasmic domain. CD200 is widely expressed by a variety of cell types. It interacts with CD200R another Ig superfamily inhibitory receptor primarily expresses on leukocytes of the myeloid lineage to inhibit myeloid functions. It has been shown to be up regulated in CLL. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.