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CD1B
CD1b molecule
CD1B is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.
| Gene Name: | CD1b molecule |
| Synonyms: | CD1B, CD1, CD1b molecule, CD1b antigen, CD1B antigen, b polypeptide |
| Target Sequences: | NM_001764 NP_001755.1 P29016 |
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