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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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CD121b / IL1R2
interleukin 1 receptor, type II
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
| Gene Name: | interleukin 1 receptor, type II |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL1R2, CD121b, CD121b antigen, CDw121b, IL-1RT-2, IL1R2c, Interleukin-1 receptor beta, Interleukin-1 receptor type II, IL-1R-beta, Antigen CDw121b, IL-1 type II receptor, IL-1R-2, IL-1RT2, IL1RB, Interleukin-1 receptor type 2 |
| Target Sequences: | NM_004633 NP_004624.1 P27930 |
Publications (1)
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