CD110 / MPL

myeloproliferative leukemia virus oncogene

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

CD110 / MPL (8)

Publications

No (8)

Tag

GST (1)

His (2)

His,C-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (1)

Rat (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Rat CD110 / MPL Protein (Recombinant His,C-terminus) (Met1-Ala500) - LS-G138201

Source:

Baculovirus

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

55.1 kDa

Price:

50 µg/$483

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Mouse CD110 / MPL Protein (Recombinant His-T7) (aa66-260) - LS-G13847

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.2 kDa

Price:

10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329

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CD110 / MPL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116015

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.24 kDa

Price:

100 µg/$710

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Human CD110 / MPL Protein (Recombinant His) (aa26-491) - LS-G20975

Source:

E. coli

Tag:

His

Molecular Weight:

56.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human CD110 / MPL Protein (Recombinant GST) (Full Length) - LS-G29366

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

97.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CD110 / MPL Protein (Recombinant His) (aa26-491) - LS-G23033

Source:

Yeast

Tag:

His

Molecular Weight:

54.5 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human CD110 / MPL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79148

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.24 kDa

Price:

20 µg/$215

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Human CD110 / MPL Protein (Recombinant His-T7) (aa311-460) - LS-G13846

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.4 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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