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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CD110 / MPL

myeloproliferative leukemia virus oncogene

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Gene Name: myeloproliferative leukemia virus oncogene
Synonyms: MPL, CD110 antigen, C-MPL, CD110, MPLV, Proto-oncogene c-Mpl, TPOR, TPO-R, THCYT2, Thrombopoietin receptor
Target Sequences: NM_005373 NP_005364.1 P40238

Filtered by: None
Target
CD110 / MPL (43)
Reactivity
Human (43)
Mouse (17)
Rat (1)
Hamster (1)
Monkey (1)
Application
IHC (24)
IHC-P (9)
WB (38)
Flo (4)
ELISA (10)
IF (1)
IP (7)
Host
rabbit (39)
mouse (4)
Isotype
Ig (2)
IgG (20)
IgG2a (2)
IgG2b (2)
Clonality
monoclonal mc (4)
polyclonal pc (39)
Clone
1D6B7 (1)
1H2 (2)
Format
AP Conjugated (2)
APC (2)
APC Conjugated (4)
Biotin Conjugated (5)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (5)
Unconjugated (13)
Epitope
aa311-460 (8)
aa66-260 (8)
C-Terminus (2)
321-370 aa, Internal (1)
Internal (1)
N-Terminus (1)
aa1-635 (1)
aa615-628 (1)
Publications
No (42)
Yes (1)
Showing 1-25 of 43 results

CD110 / MPL Antibody (aa615-628) LS-C26341
Publications (1)
Publications (1)
Rabbit Polyclonal (IgG) to Human CD110 / MPL
Mouse, Hamster, Human, Monkey
IHC IP WB
Unconjugated
200µg  $650.00
WB: DAMI cell lysate probed with Thrombopoietin Receptor (c-Mpl) (TPO) (0.5 ug/ml).

CD110 / MPL Antibody (HRP) LS-C549813
Rabbit Polyclonal (IgG) to Human CD110 / MPL
Mouse, Human
IHC IP WB
HRP Conjugated
100µl  $830.00

CD110 / MPL Antibody (Biotin) LS-C529725
Rabbit Polyclonal (IgG) to Human CD110 / MPL
Mouse, Human
IHC IP WB
Biotin Conjugated
100µl  $830.00

CD110 / MPL Antibody (AP) LS-C511621
Rabbit Polyclonal (IgG) to Human CD110 / MPL
Mouse, Human
IHC IP WB
AP Conjugated
100µl  $830.00

CD110 / MPL Antibody (APC) LS-C519510
Rabbit Polyclonal (IgG) to Human CD110 / MPL
Mouse, Human
IHC IP WB
APC Conjugated
100µl  $830.00

CD110 / MPL Antibody (PE) LS-C657787
Rabbit Polyclonal (IgG) to Human CD110 / MPL
Mouse, Human
IHC IP WB
PE Conjugated
100µl  $830.00

CD110 / MPL Antibody (PE) LS-C144232
Mouse Monoclonal (IgG2a) to Human CD110 / MPL
Human
Flo
PE Conjugated
100tst  $665.00

CD110 / MPL Antibody (aa66-260) LS-C295475
Rabbit Polyclonal to Mouse CD110 / MPL
Mouse, Human
IHC IHC-P WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $515.00; 10ml 0.5mg/ml  $2,040.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD110 / MPL Antibody (aa66-260, HRP) LS-C709735
Rabbit Polyclonal to Mouse CD110 / MPL
Mouse, Human
IHC IHC-P WB
HRP Conjugated
100µl 0.5mg/ml  $285.00; 200µl 0.5mg/ml  $335.00; 1ml 0.5mg/ml  $665.00; 10ml 0.5mg/ml  $2,655.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD110 / MPL Antibody (aa66-260, Biotin) LS-C685938
Rabbit Polyclonal to Mouse CD110 / MPL
Mouse, Human
IHC IHC-P WB
Biotin Conjugated
100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $560.00; 10ml 0.5mg/ml  $2,250.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD110 / MPL Antibody (aa66-260, FITC) LS-C692505
Rabbit Polyclonal to Mouse CD110 / MPL
Mouse, Human
IHC IHC-P WB
FITC Conjugated
100µl 0.5mg/ml  $275.00; 200µl 0.5mg/ml  $325.00; 1ml 0.5mg/ml  $620.00; 10ml 0.5mg/ml  $2,460.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD110 / MPL Antibody (aa66-260, Cy3) LS-C700712
Rabbit Polyclonal to Mouse CD110 / MPL
Mouse, Human
IHC IHC-P WB
Cy3 Conjugated
100µl 0.5mg/ml  $355.00; 200µl 0.5mg/ml  $435.00; 1ml 0.5mg/ml  $1,020.00; 10ml 0.5mg/ml  $4,095.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD110 / MPL Antibody (aa66-260, APC, Cy7) LS-C732786
Rabbit Polyclonal to Mouse CD110 / MPL
Mouse, Human
IHC IHC-P WB
APC, Cy7 Conjugated
100µl  $445.00; 200µl  $620.00; 1ml  $1,530.00; 10ml  $6,150.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD110 / MPL Antibody (aa66-260, PE) LS-C723795
Rabbit Polyclonal to Mouse CD110 / MPL
Mouse, Human
IHC IHC-P WB
PE Conjugated
100µl  $275.00; 200µl  $325.00; 1ml  $620.00; 10ml  $2,460.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD110 / MPL Antibody (aa66-260, APC) LS-C716879
Rabbit Polyclonal to Mouse CD110 / MPL
Mouse, Human
IHC IHC-P WB
APC Conjugated
100µl  $305.00; 200µl  $365.00; 1ml  $770.00; 10ml  $4,140.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD110 / MPL Antibody (C-Terminus) LS-C193945
Rabbit Polyclonal (IgG) to Human CD110 / MPL
Human
WB
Unconjugated
100µg 1ml  $860.00

CD110 / MPL Antibody LS-C678675
Rabbit Polyclonal (IgG) to Human CD110 / MPL
Human
ELISA IF IHC IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human spleen tissue at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution of 1:100

CD110 / MPL Antibody (clone 1D6B7) LS-C682570
Mouse Monoclonal [clone 1D6B7] (IgG2a) to Human CD110 / MPL
Human
ELISA Flo WB
Unconjugated
100µl  $365.00

CD110 / MPL Antibody (clone 1H2) LS-C169168
Mouse Monoclonal [clone 1H2] (IgG2b) to Human CD110 / MPL
Human
ELISA Flo WB
Unconjugated
100µg 1mg/ml  $365.00
Western blot using MPL monoclonal antibody against human MPL (AA: 307-362) recombinant protein. (Expected MW is 32.2 kDa)
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);

CD110 / MPL Antibody (aa311-460) LS-C295474
Rabbit Polyclonal to Human CD110 / MPL
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $495.00; 10ml 0.5mg/ml  $1,980.00
Immunohistochemistry - Paraffin Image
Western blot of recombinant CD110 / MPL.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CD110 / MPL Antibody (aa311-460, Cy3) LS-C700710
Rabbit Polyclonal to Human CD110 / MPL
Human
IHC WB
Cy3 Conjugated
100µl 0.5mg/ml  $345.00; 200µl 0.5mg/ml  $425.00; 1ml 0.5mg/ml  $995.00; 10ml 0.5mg/ml  $3,975.00
Immunohistochemistry - Paraffin Image
Western blot of recombinant CD110 / MPL.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CD110 / MPL Antibody (aa311-460, PE) LS-C723790
Rabbit Polyclonal to Human CD110 / MPL
Human
IHC WB
PE Conjugated
100µl  $275.00; 200µl  $315.00; 1ml  $590.00; 10ml  $2,385.00
Immunohistochemistry - Paraffin Image
Western blot of recombinant CD110 / MPL.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CD110 / MPL Antibody (aa311-460, APC, Cy7) LS-C732785
Rabbit Polyclonal to Human CD110 / MPL
Human
IHC WB
APC, Cy7 Conjugated
100µl  $435.00; 200µl  $590.00; 1ml  $1,485.00; 10ml  $5,970.00
Immunohistochemistry - Paraffin Image
Western blot of recombinant CD110 / MPL.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CD110 / MPL Antibody (aa311-460, APC) LS-C716877
Rabbit Polyclonal to Human CD110 / MPL
Human
IHC WB
APC Conjugated
100µl  $295.00; 200µl  $355.00; 1ml  $740.00; 10ml  $5,505.00
Immunohistochemistry - Paraffin Image
Western blot of recombinant CD110 / MPL.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

CD110 / MPL Antibody (clone 1H2) LS-C759670
Mouse Monoclonal [clone 1H2] (IgG2b) to Human CD110 / MPL
Human
Flo WB
Unconjugated
100µg  $405.00
c-Mpl Antibody in Western Blot (WB)
c-Mpl Antibody in Flow Cytometry (Flow)
Showing 1-25 of 43 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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