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CCT2 / CCT Beta

chaperonin containing TCP1, subunit 2 (beta)

This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the gene described in this record have been observed but have not been thoroughly characterized.

Gene Name: chaperonin containing TCP1, subunit 2 (beta)
Synonyms: CCT2, 99D8.1, CCT-beta, CCTB, PRO1633, TCP-1-beta, TCP1 Beta
Target Sequences: NM_006431 NP_006422.1 P78371

Publications (3)

1
Targeting chaperonin containing TCP1 (CCT) as a molecular therapeutic for small cell lung cancer. Carr AC, Khaled AS, Bassiouni R, Flores O, Nierenberg D, Bhatti H, Vishnubhotla P, Manuel JP, Santra S, Khaled AR. Oncotarget. 2017 8:110273-110288. (WB; Human) [Full Text Article] [PubMed:29299146] Related Antibodies: LS-B4861.
2
Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. Anne E Showalter , Ana C Martini , Daniel Nierenberg, Kristen Hosang, Naima Ahmed Fahmi, Priya Gopalan, Amr S Khaled, Wei Zhang, Annette R Khaled. Scientific reports. 2020 Jan;10:798. [Full Text Article] [PubMed:31964905] [PMC:PMC6972895] Related Antibodies: LS-B4861.
3
Chaperonin containing TCP1 as a marker for identification of circulating tumor cells in blood. Amanda Cox, Ana Martini, Heba Ghozlan, Rebecca Moroose, Xiang Zhu, Eunkyung Lee, Amr S Khaled, Louis Barr, Carlos Alemany, Na'im Fanaian, Elizabeth Griffith, Ryan Sause, S A Litherland, Annette R Khaled. PloS one. 2022 June;17:e0264651. [Full Text Article] [PubMed:35749519] [PMC:PMC9232171] Related Antibodies: LS-C649415.

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Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
CCT2 / CCT Beta (7)
No (7)
6His, N-terminus (1)
GST, N-terminus (1)
His-S (1)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (1)
CCT2 / CCT Beta Protein - Recombinant  Chaperonin Containing TCP1, Subunit 2 By SDS-PAGE
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E. coli
His-S
56.4 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
CCT2 / CCT Beta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
57.3 kDa
100 µg/$710
CCT2 / CCT Beta Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CCT2 / CCT Beta Protein
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E. coli
His-SUMO
73.36 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CCT2 / CCT Beta Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
CCT2 / CCT Beta Protein - Purified recombinant protein CCT2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
57.3 kDa
20 µg/$1,107
CCT2 / CCT Beta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
57.3 kDa
20 µg/$215
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).