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CCN5

WNT1 inducible signaling pathway protein 2

WISP2 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Gene Name: WNT1 inducible signaling pathway protein 2
Synonyms: WISP2, CCN5, CCN family member 5, CTGFL, CT58, CTGF-L, WISP-2
Target Sequences: NM_003881 NP_003872.1 O76076

Publications (2)

1
RNA-sequencing highlights differential regulated pathways involved in cell cycle and inflammation in orbitofacial neurofibromas. Eddie Luidy Imada, Diego Strianese, Deepak P Edward, Rawan alThaqib, Antionette Price, Antje Arnold, Hailah Al-Hussain, Luigi Marchionni, Fausto J Rodriguez. Brain pathology (Zurich, Switzerland). 2022 January;32:e13007. [Full Text Article] [PubMed:34297428] [PMC:PMC8713532] Related Antibodies: LS-B6392.
2
Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction. Sima Zolfaghari, Ole Jørgen Kaasbøll, M Shakil Ahmed, Fabian A Line, Else Marie V Hagelin, Vivi T Monsen, Håvard Attramadal. Journal of cell communication and signaling. 2021 December;16:377-395. [Full Text Article] [PubMed:34854055] [PMC:PMC9411331] Related Antibodies: LS-C349158.

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CCN5 ELISA Kit
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0.313 - 20 ng/ml
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1 Plate/$730
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0.156 - 10 ng/ml
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1 Plate/$669
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0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$669
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96-Well Strip Plate
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Colorimetric - 450nm (TMB)
1 Plate/$669
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96-Well Strip Plate
Human
27.43 - 20000 pg/ml
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1 Plate/$851
CCN5 ELISA Kit
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Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$579
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).