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CCL3 / MIP-1-Alpha

chemokine (C-C motif) ligand 3

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

Gene Name:	chemokine (C-C motif) ligand 3
Family/Subfamily:	Intercrine , Intercrine beta
Synonyms:	CCL3, C-C motif chemokine 3, G0S19-1, Mip1alpha, SCYA3, SIS-beta, Chemokine (C-C motif) ligand 3, LD78ALPHA, MIP-1-alpha, MIP1A, PAT 464.1, Small-inducible cytokine A3
Target Sequences:	NM_002983 NP_002974.1

Publications (2)

Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study. Xu J, Alexander DB, Iigo M, Hamano H, Takahashi S, Yokoyama T, Kato M, Usami I, Tokuyama T, Tsutsumi M, Tamura M, Oguri T, Niimi A, Hayashi Y, Yokoyama Y, Tonegawa K, Fukamachi K, Futakuchi M, Sakai Y, Suzui M, Kamijima M, Hisanaga N, Omori T, Nakae D, Hirose A, Kanno J, Tsuda H. Cancer science. 2015 106:825-32. (IHC-P; Human) [Full Text Article] [PubMed:25940505] [PMC:PMC4520633]

CCL3-CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways. Takayuki Kodama, Yu-Ichiro Koma, Noriaki Arai, Aya Kido, Naoki Urakawa, Mari Nishio, Manabu Shigeoka, Hiroshi Yokozaki. Laboratory investigation; a journal of technical methods and pathology. 2020 September;100:1140-1157. [Full Text Article] [PubMed:32457351] [PMC:PMC7438203] Related Antibodies: LS-C384561.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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