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CCL17 / TARC

chemokine (C-C motif) ligand 17

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.

Gene Name: chemokine (C-C motif) ligand 17
Family/Subfamily: Intercrine , Intercrine beta
Synonyms: CCL17, A-152E5.3, C-C motif chemokine 17, CC chemokine abcd-2, ABCD-2, SCYA17, T cell-directed CC chemokine, TARC, CC chemokine TARC, Small-inducible cytokine A17
Target Sequences: NM_002987 NP_002978.1 Q92583

Publications (1)

1
Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin. Omland SH, Wettergren EE, Mollerup S, Asplund M, Mourier T, Hansen AJ, Gniadecki R. BMC cancer. 2017 17:675. (IHC, ELISA; Human) [Full Text Article] [PubMed:28987144] [PMC:PMC5806272] Related Antibodies: LS-C198166.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).