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This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
Gene Name: | chemokine (C-C motif) ligand 17 |
Family/Subfamily: | Intercrine , Intercrine beta |
Synonyms: | CCL17, A-152E5.3, C-C motif chemokine 17, CC chemokine abcd-2, ABCD-2, SCYA17, T cell-directed CC chemokine, TARC, CC chemokine TARC, Small-inducible cytokine A17 |
Target Sequences: | NM_002987 NP_002978.1 Q92583 |
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