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CBX4
chromobox homolog 4
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
| Gene Name: | chromobox homolog 4 |
| Synonyms: | CBX4, Chromobox homolog 4, Chromobox protein homolog 4, E3 SUMO-protein ligase CBX4, NBP16, NS5ATP1-binding protein 16, HPC2, Polycomb 2 homolog, PC2, Pc class 2 homolog |
| Target Sequences: | NM_003655 NP_003646.2 O00257 |
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