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CBX1 / HP1 Beta
chromobox homolog 1
CBX1 / HP1 Beta is a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.
| Gene Name: | chromobox homolog 1 |
| Synonyms: | CBX1, CBX, Chromobox protein homolog 1, HP1 beta, HP1Hs-beta, Heterochromatin protein 1-beta, HP1Hsbeta, M31, Modifier 1 protein, MOD1, HP1 beta homolog, HP1-BETA, Chromobox homolog 1, Heterochromatin protein p25, p25beta |
| Target Sequences: | NM_006807 NP_006798.1 P83916 |
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