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CBS

cystathionine-beta-synthase

Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.

Gene Name:	cystathionine-beta-synthase
Synonyms:	CBS, Beta-thionase, Cystathionine beta-synthase, HIP4, Methylcysteine synthase, Serine sulfhydrase, Cystathionine-beta-synthase
Target Sequences:	NM_000071 NP_000062.1 P35520

Publications (1)

The H2S-generating enzymes cystathionine ß-synthase and cystathionine ?-lyase play a role in vascular development during normal lung alveolarization. Madurga A, Golec A, Pozarska A, Ishii I, Mižíková I, Nardiello C, Vadász I, Herold S, Mayer K, Reichenberger F, Fehrenbach H, Seeger W, Morty RE. American journal of physiology. Lung cellular and molecular physiology. 2015 October;309:L710-L724. [Full Text Article] [PubMed:26232299]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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