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CBLN1 / Cerebellin 1

cerebellin 1 precursor

Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion.

Gene Name: cerebellin 1 precursor
Synonyms: CBLN1, CLN1, Cerebellin, Cerebellin 1 precursor, Precerebellin, Cerebellin-1
Target Sequences: NM_004352 NP_004343.1 P23435

Publications (2)

1
Chronic hyperoxia alters the expression of neurotrophic factors in the carotid body of neonatal rats. Dmitrieff EF, Wilson JT, Dunmire KB, Bavis RW. Respiratory Physiology & Neurobiology. 2011 175:220-7. (IHC-Fr; Rat) [Full Text Article] [PubMed:21094282] [PMC:PMC3033470] Related Antibodies: LS-B478.
2
Altered Cerebellar Circuitry following Thoracic Spinal Cord Injury in Adult Rats. Visavadiya NP, Springer JE. Neural plasticity. 2016 2016:8181393. (WB; Human) [Full Text Article] [PubMed:27504204] [PMC:PMC4967704] Related Antibodies: LS-C119839.

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Antibodies (19)
Primary (19)
CBLN1 / Cerebellin 1 (19)
Human (19)
Mouse (9)
Rat (9)
Bat (3)
Bovine (4)
Chicken (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (4)
Pig (4)
Rabbit (3)
Xenopus (3)
Zebrafish (3)
IHC (1)
IHC-Fr (1)
IHC-P (1)
WB (19)
ELISA (4)
ICC (1)
IF (1)
Peptide-ELISA (2)
rabbit (19)
Product Group
IHCPlus (1)
IgG (6)
polyclonal pc (19)
APC (1)
APC Conjugated (1)
Biotin Conjugated (2)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (9)
aa22-193 (8)
C-Terminus (5)
100-180 aa, C-terminal (1)
aa131-180 (1)
No (17)
Yes (2)
CBLN1 / Cerebellin 1 Antibody - Anti-CBLN1 / Precerebellin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.05 mg/$545
CBLN1 / Cerebellin 1 Antibody - Western blot analysis of lysates from HUVEC cells, using CBLN1 Antibody. The lane on the right is blocked with the synthesized peptide.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (aa131-180) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CBLN1 / Cerebellin 1 Antibody - Immunocytochemistry of precerebellin in 3T3 cells with precerebellin antibody at 10 ug/ml.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, WB
Unconjugated
0.1 mg/$460
CBLN1 / Cerebellin 1 Antibody - Western blot of Cerebellin 1 antibody
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (100-180 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CBLN1 / Cerebellin 1 Antibody - Staining HuvEc cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CBLN1 / Cerebellin 1 Antibody - Western blot analysis of extracts from HUVEC cells, using CBLN1 antibody.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
CBLN1 / Cerebellin 1 Antibody - CBLN1 antibody Western blot of Jurkat lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
CBLN1 / Cerebellin 1 Antibody - CBLN1 antibody Western blot of Jurkat lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
WB
HRP Conjugated
100 µl/$469
CBLN1 / Cerebellin 1 Antibody - CBLN1 antibody Western blot of Jurkat lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
CBLN1 / Cerebellin 1 Antibody - CBLN1 antibody Western blot of Jurkat lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
WB
FITC Conjugated
100 µl/$469
CBLN1 / Cerebellin 1 Antibody - Western blot of CBLN1 / Cerebellin 1 antibody.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (aa22-193) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
CBLN1 / Cerebellin 1 Antibody - Western blot of CBLN1 / Cerebellin 1 antibody.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (aa22-193) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
CBLN1 / Cerebellin 1 Antibody - Western blot of CBLN1 / Cerebellin 1 antibody.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (aa22-193) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
CBLN1 / Cerebellin 1 Antibody - Western blot of CBLN1 / Cerebellin 1 antibody.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (aa22-193) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
CBLN1 / Cerebellin 1 Antibody - Western blot of CBLN1 / Cerebellin 1 antibody.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (aa22-193) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
CBLN1 / Cerebellin 1 Antibody - Western blot of CBLN1 / Cerebellin 1 antibody.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (aa22-193) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
CBLN1 / Cerebellin 1 Antibody - Western blot of CBLN1 / Cerebellin 1 antibody.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (aa22-193) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
CBLN1 / Cerebellin 1 Antibody - Western blot of CBLN1 / Cerebellin 1 antibody.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (aa22-193) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
CBLN1 / Cerebellin 1 Antibody - Western blot analysis of Cerebellin 1 expression in HEK293T (A); SP2/0 (B); PC12 (C) whole cell lysates.
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CBLN1 / Cerebellin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
WB
Unconjugated
100 µl/$299
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).