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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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CBLL1 / HAKAI
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CBLL1 / HAKAI is an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
| Gene Name: | Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase |
| Synonyms: | CBLL1, C-Cbl-like protein 1, E-cadherin binding protein E7, HAKAI, RING finger protein 188, RNF188 |
| Target Sequences: | NM_024814 NP_079090.2 Q75N03 |
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