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CASR/Calcium Sensing Receptor

calcium-sensing receptor

CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing.

Gene Name: calcium-sensing receptor
Family/Subfamily: GPCR , Calcium-sensing
Synonyms: CASR, Ca sensing receptor, Ca2+ sensing receptor, Calcium-sensing receptor, FIH, EIG8, GPRC2A, HHC, HHC1, Hypocalciuric hypercalcemia 1, PCAR1, NSHPT, CAR, FHH
Target Sequences: NM_000388 NP_000379.2 P41180

Publications (3)

1
The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway. Handlogten ME, Huang C, Shiraishi N, Awata H, Miller RT. The Journal of biological chemistry. 2001 276:13941-8. [PubMed:11278341]
2
Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. Awata H, Huang C, Handlogten ME, Miller RT. The Journal of biological chemistry. 2001 276:34871-9. [PubMed:11390379]
3
Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney. Graca JA, Schepelmann M, Brennan SC, Reens J, Chang W, Yan P, Toka H, Riccardi D, Price SA. American journal of physiology. Renal physiology. 2016 310:F518-33. (WB; Human) [Full Text Article] [PubMed:26661650] [PMC:PMC5005276] Related Antibodies: LS-C117834.

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ELISA Kits (22)
Cell-Based (1)
Cell-Based Phosphorylation (1)
Competitive EIA (1)
Custom (3)
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Sandwich CLIA (1)
CASR/Calcium Sensing Receptor (22)
Human (6)
Mouse (6)
Rat (7)
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Monkey (1)
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96-Well Microplate (4)
96-Well Strip Plate (17)
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Cell Lysates (3)
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Serum (9)
Tissue Homogenates (6)
CASR/Calcium Sensing Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CASR/Calcium Sensing Receptor ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
CASR/Calcium Sensing Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CASR/Calcium Sensing Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CASR/Calcium Sensing Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CASR/Calcium Sensing Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CASR/Calcium Sensing Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CASR/Calcium Sensing Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CASR/Calcium Sensing Receptor ELISA Kit
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Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
CASR/Calcium Sensing Receptor ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
CASR/Calcium Sensing Receptor ELISA Kit
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Competitive EIA
96-Well Strip Plate
Bovine
0.15 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CASR/Calcium Sensing Receptor ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
CASR/Calcium Sensing Receptor ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CASR/Calcium Sensing Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
CASR/Calcium Sensing Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$893
CASR/Calcium Sensing Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CASR/Calcium Sensing Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CASR/Calcium Sensing Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CASR/Calcium Sensing Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CASR/Calcium Sensing Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CASR/Calcium Sensing Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$854
CASR/Calcium Sensing Receptor ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).