CASP8 / Caspase 8

caspase 8, apoptosis-related cysteine peptidase

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

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Proteins (16)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (5)

Recombinant (10)

Target

CASP8 / Caspase 8 (16)

Publications

No (16)

Tag

6His, N-terminus (2)

His (3)

His, N-Terminal (1)

His-T7 (6)

Myc-DDK (Flag) (4)

Species

Bovine (1)

Human (8)

Mouse (4)

Rat (1)

Source

293T Cells (2)

E. coli (10)

HEK 293 Cells (4)

Low Endotoxin Level

Low endotoxin level (1)

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Mouse CASP8 / Caspase 8 Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Ser219-Pro480) - LS-G26822

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

30 kDa

Price:

200 µl/$283

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CASP8 / Caspase 8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118713

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.5 kDa

Price:

100 µg/$710

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Human CASP8 / Caspase 8 Protein (Recombinant His, N-Terminal) - LS-G144534

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

61.7 kDa

Price:

50 µg/$419

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Human CASP8 / Caspase 8 Protein (Recombinant His) - LS-G22749

Source:

E. coli

Tag:

His

Molecular Weight:

22 kD

Price:

20 µg/$323; 1 mg/$1,355; 100 µg/$420

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Rat CASP8 / Caspase 8 Protein (Recombinant His-T7) (aa8-197) - LS-G24142

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.8 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Mouse CASP8 / Caspase 8 Protein (Over-Expression Lysate 6His, N-terminus) (Ser219-Pro480) - LS-G26673

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

30 kDa

Price:

100 µg/$298

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Human CASP8 / Caspase 8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75040

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.5 kDa

Price:

20 µg/$215

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Human CASP8 / Caspase 8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75041

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.2 kDa

Price:

20 µg/$215

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CASP8 / Caspase 8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102129

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.2 kDa

Price:

100 µg/$710

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Human CASP8 / Caspase 8 Protein (Recombinant His) (aa365-479) - LS-G140884

Source:

E. coli

Sequence Length:

114 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

12.65 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Bovine CASP8 / Caspase 8 Protein (Recombinant His) (aa25-175) - LS-G12987

Source:

E. coli

Tag:

His

Molecular Weight:

19.7 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Human CASP8 / Caspase 8 Protein (Recombinant His-T7) (aa217-384) - LS-G12988

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.9 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human CASP8 / Caspase 8 Protein (Recombinant His-T7) (aa385-479) - LS-G12991

Source:

E. coli

Tag:

His-T7

Molecular Weight:

14.7 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human CASP8 / Caspase 8 Protein (Recombinant His-T7) (aa7-216) - LS-G12997

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.2 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Mouse CASP8 / Caspase 8 Protein (Recombinant His-T7) (aa219-376) - LS-G12999

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.6 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Mouse CASP8 / Caspase 8 Protein (Recombinant His-T7) (aa1-218) - LS-G13003

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.4 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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