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CASP1 / Caspase 1
caspase 1, apoptosis-related cysteine peptidase
CASP1 / Caspase 1 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
| Gene Name: | caspase 1, apoptosis-related cysteine peptidase |
| Family/Subfamily: | Protease , Cysteine C14 |
| Synonyms: | CASP1, Caspase-1, CASP-1, CASP1 nirs variant 1, Caspase 1, ICE, ICE-like protease, IL-1 beta-converting enzyme, IL-1BC, IL1BC, IL1BCE, p45, IL1B-convertase, Interleukin-1 beta convertase |
| Target Sequences: | NM_001223 NP_001214.1 P29466 |
Publications (1)
1
Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats. Ghada A Badawi, Mustafa M Shokr, Hala F Zaki, Ahmed F Mohamed. Clinical and experimental pharmacology & physiology. 2021 August;48:1111-1124. [Full Text Article]
[PubMed:33899956]
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Antibodies
(115)
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(115)
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CASP1 / Caspase 1
(115)
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(108)
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(1)
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(48)
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(3)
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(109)
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(6)
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(10)
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(10)
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(62)
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Publications
No
(115)
CASP1 / Caspase 1 Mouse anti-Human Monoclonal (aa371-390) (14F468) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CASP1 / Caspase 1 Rat anti-Mouse Monoclonal (aa206-220) (1H11) Antibody
Mouse
ELISA, Flo, WB
Unconjugated
100 µg/$755
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa249-262) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (130-210 aa, Internal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa120-297) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa317-404) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
CASP1 / Caspase 1 Mouse anti-Human Monoclonal (3D2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CASP1 / Caspase 1 Rabbit anti-Pig Polyclonal (aa120-297) Antibody
Pig, Human
ICC, IP, WB
Unconjugated
100 µl/$323; 200 µl/$371; 500 µl/$531; 1 ml/$617; 2 ml/$850; 5 ml/$1,401
CASP1 / Caspase 1 Rabbit anti-Pig Polyclonal (aa120-297) (Biotin) Antibody
Pig, Human
WB
Biotin Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$563; 1 ml/$678; 2 ml/$915; 5 ml/$1,541
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa225-242) Antibody
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
100 µg/$854
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (170-250 aa, Internal) Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP1 / Caspase 1 Rabbit anti-Insect Polyclonal (N-Terminus) Antibody
ELISA, WB
Unconjugated
0.1 mg/$379
CASP1 / Caspase 1 Rabbit anti-Mouse Polyclonal (aa137-157) Antibody
Mouse, Rat
WB
Unconjugated
10 µg/$318; 100 µg/$470
CASP1 / Caspase 1 Rabbit anti-Rat Polyclonal (aa119-296) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa135-152) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa31-45) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.1 mg/$386
CASP1 / Caspase 1 Rabbit anti-Mouse Polyclonal (aa119-296) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
CASP1 / Caspase 1 Rabbit anti-Mouse Polyclonal (aa119-296) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
CASP1 / Caspase 1 Mouse anti-Human Monoclonal (aa203-400) (ABM1B93) Antibody
Mouse, Human
WB
Unconjugated
25 µg/$288; 100 µg/$414
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa30-79) Antibody
Human
WB
Unconjugated
100 µl/$424
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (aa30-79) (Biotin) Antibody
Horse, Human
WB
Biotin Conjugated
100 µl/$469
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
CASP1 / Caspase 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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product results
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