CASC5

cancer susceptibility candidate 5

CASC5 is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.

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Proteins (2)

Type

Recombinant (2)

Target

CASC5 (2)

Publications

No (2)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

Species

Human (1)

Mouse (1)

Source

E. coli (1)

Wheat Germ Extract (1)

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Human CASC5 Protein (Recombinant GST, N-terminus) (aa3-98) - LS-G62905

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse CASC5 Protein (Recombinant His, N-Terminal) (Met1-Ser230) - LS-G133179

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

29.7kDa

Price:

10 µg/$271; 50 µg/$382; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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