CASC3 / MLN51

cancer susceptibility candidate 3

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CASC3 / MLN51 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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CASC3 / MLN51 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114676

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.1 kDa

Price:

100 µg/$494

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Human CASC3 / MLN51 Protein (Recombinant GST, N-terminus) (aa604-703) - LS-G61838

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CASC3 / MLN51 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69208

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.1 kDa

Price:

20 µg/$1,107

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Human CASC3 / MLN51 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84087

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.1 kDa

Price:

20 µg/$150

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