CARD9

caspase recruitment domain family, member 9

Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.

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Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

CARD9 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (6)

Species

Human (7)

Mouse (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CARD9 Protein (Recombinant GST) (Full Length) - LS-G34947

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

83.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CARD9 Protein (Recombinant His-T7) (aa26-283) - LS-G26219

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.7 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human CARD9 Protein (Recombinant GST, N-terminus) (aa393-492) - LS-G63077

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CARD9 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69790

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.1 kDa

Price:

20 µg/$1,107

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Human CARD9 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69793

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.5 kDa

Price:

20 µg/$1,107

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Human CARD9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85555

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.1 kDa

Price:

20 µg/$215

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Human CARD9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85556

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.5 kDa

Price:

20 µg/$150

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CARD9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108174

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.1 kDa

Price:

100 µg/$710

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CARD9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127284

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.5 kDa

Price:

100 µg/$494

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Mouse CARD9 Protein (Recombinant His-T7) (aa274-530) - LS-G16266

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.8 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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