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Carboxypeptidase Z / CPZ

carboxypeptidase Z

The major form of CPZ mRNA in human salivary gland encodes a protein with an open reading frame of 641 amino acids. In addition, three variants were found that presumably arise due to alternative intron splicing. The 641 amino acid protein contains an 18 residue signal peptide-like sequence, a 120 residue region that shows 23-29% amino acid identity with a Cys-rich domain found in frizzled proteins and in type XVIII collagen, and then a 390 residue carboxypeptidase domain with 49% amino acid identity to carboxypeptidases E and N. The CPZ activity is more active at neutral pH than at pH 5.5 and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. CPZ is a metallocarboxypeptidase that is active toward substrates with C-terminal basic amino acids.

Gene Name: carboxypeptidase Z
Family/Subfamily: Exopeptidase , Metallopeptidase M14
Synonyms: CPZ, Carboxypeptidase Z, Metallocarboxypeptidase Z
Target Sequences: NM_003652 NP_003643.2 Q66K79

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Proteins (5)
Over-Expression Lysate (4)
Recombinant (1)
Carboxypeptidase Z / CPZ (5)
No (5)
His-T7 (1)
Myc-DDK (Flag) (4)
Human (3)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Carboxypeptidase Z / CPZ Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
72.5 kDa
100 µg/$710
Carboxypeptidase Z / CPZ Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
73.63 kDa
100 µg/$494
Carboxypeptidase Z / CPZ Protein - Recombinant Carboxypeptidase Z By SDS-PAGE
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E. coli
His-T7
29.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Carboxypeptidase Z / CPZ Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
72.5 kDa
20 µg/$215
Carboxypeptidase Z / CPZ Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
73.63 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).