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CANX / Calnexin

calnexin

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

Gene Name: calnexin
Synonyms: CANX, CNX, Calnexin, IP90, p90
Target Sequences: NM_001746 NP_001737.1 P27824

Publications (5)

1
Characterization of zebrafish von Willebrand factor reveals conservation of domain structure, multimerization, and intracellular storage. Ghosh A, Vo A, Twiss BK, Kretz CA, Jozwiak MA, Montgomery RR, Shavit JA. Advances in hematology. 2012 2012:214209. (ICC; Human) [PubMed:23049555] [PMC:PMC3462383]
2
Alphavirus vector-based replicon particles expressing multivalent cross-protective Lassa virus glycoproteins. Wang M, Jokinen J, Tretyakova I, Pushko P, Lukashevich IS. Vaccine. 2018 36:683-690. (WB; Human) [Full Text Article] [PubMed:29287681] Related Antibodies: LS-B6014.
3
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie Cy Wang, Andrew J Davison, Gavin Wg Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes. eLife. 2019 Dec;8:e49894. [Full Text Article] [PubMed:31873071] [PMC:PMC6959991] Related Antibodies: LS-B6881.
4
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy. Marieke C Verweij , Scott G Hansen , Ravi Iyer , Nessy John , Daniel Malouli, David Morrow, Isabel Scholz, Jennie Womack, Shaheed Abdulhaqq, Roxanne M Gilbride, Colette M Hughes, Abigail B Ventura, Julia C Ford, Andrea N Selseth, Kelli Oswald, Rebecca Shoemaker, Brian Berkemeier, William J Bosche, Michael Hull, Jason Shao, Jonah B Sacha, Michael K Axthelm, Paul T Edlefsen, Jeffrey D Lifson, Louis J Picker, Klaus Früh. Science (New York, N.Y.). 2021 April;372:eabe9233. [Full Text Article] [PubMed:33766941] [PMC:PMC8354429] Related Antibodies: LS-B12410.
5
Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection. Jonas D Albarnaz , Joanne Kite , Marisa Oliveira , Hanqi Li, Ying Di, Maria H Christensen, Joao A Paulo, Robin Antrobus, Steven P Gygi, Florian I Schmidt, Edward L Huttlin, Geoffrey L Smith, Michael P Weekes. Nature communications. 2023 December;14:8134. [Full Text Article] [PubMed:38065956] [PMC:PMC10709566] Related Antibodies: LS-B6881.
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☰ Filters
Products
Proteins (12)
Over-Expression Lysate (4)
Recombinant (8)
CANX / Calnexin (12)
No (12)
6His, C-terminus (2)
GST, N-terminus (1)
His, N-Terminal (1)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Human (9)
Mouse (1)
293T Cells (2)
E. coli (4)
HEK 293 Cells (3)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (2)
CANX / Calnexin Protein - Purified recombinant protein CANX was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
65.3 kDa
20 µg/$1,107
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
53.48kD
10 µg/$284; 50 µg/$431; 500 µg/$1,533; 1 mg/$2,055
CANX / Calnexin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
68 kDa
100 µg/$494
CANX / Calnexin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
67.57 kDa
100 µg/$494
CANX / Calnexin Protein - Recombinant Calnexin By SDS-PAGE
Select
E. coli
His-T7
29.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
CANX / Calnexin Protein - Recombinant Calnexin By SDS-PAGE
Select
E. coli
His-GST
58.8 kDa
10 µg/$287; 50 µg/$477; 100 µg/$762; 200 µg/$952; 1 mg/$2,083; 500 µg/$1,613; 5 mg/$3,333; 2 mg/$2,272
CANX / Calnexin Protein
Select
E. coli
None
100 µg/$317; 500 µg/$526; 20 µg/$245
CANX / Calnexin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
67.57 kDa
20 µg/$150
Select
293T Cells
Myc-DDK (Flag)
68 kDa
20 µg/$150
CANX / Calnexin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
CANX / Calnexin Protein
Select
E. coli
His, N-Terminal
65.3 kDa
50 µg/$419
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
53.5 kDa
10 µg/$376; 50 µg/$526
Viewing 1-12 of 12 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).