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CAMK2D / CaMKII Delta

calcium/calmodulin-dependent protein kinase II delta

Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and phosphorylating the L-type Ca2+ channel subunit beta-2 CACNB2. In addition to Ca2+ channels, can target and regulate the cardiac sarcolemmal Na+ channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2+ uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.

Gene Name: calcium/calmodulin-dependent protein kinase II delta
Family/Subfamily: Protein Kinase , CAMK2
Synonyms: CAMK2D, CaM kinase II delta, CaM kinase II delta subunit, CaM kinase II subunit delta, CaM-kinase II delta chain, CaMK-II delta subunit, CaMKIIdelta, CaMK II delta, CAMKD, CaMK-II subunit delta, CaMKII delta, Delta CaMK-II
Target Sequences: NM_001221 NP_001212.2 Q13557

Publications (3)

1
Endothelial CaMKII as a regulator of eNOS activity and NO-mediated vasoreactivity. Murthy S, Koval OM, Ramiro Diaz JM, Kumar S, Nuno D, Scott JA, Allamargot C, Zhu LJ, Broadhurst K, Santhana V, Kutschke WJ, Irani K, Lamping KG, Grumbach IM. PloS one. 2017 12:e0186311. (WB; Human) [Full Text Article] [PubMed:29059213] [PMC:PMC5653296] Related Antibodies: LS-C100735.
2
CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis. Winters CJ, Koval O, Murthy S, Allamargot C, Sebag SC, Paschke JD, Jaffer OA, Carter AB, Grumbach IM. American journal of physiology. Lung cellular and molecular physiology. 2016 January;310:L86-94. [Full Text Article] [PubMed:26545899] [PMC:PMC4698436] Related Antibodies: LS-C100735.
3
All-trans retinoic acid attenuates isoproterenol-induced cardiac dysfunction through Crabp1 to dampen CaMKII activation. Sung Wook Park, Jennifer Nhieu, Yi-Wei Lin, Li-Na Wei. European journal of pharmacology. 2019 September;858:172485. [Full Text Article] [PubMed:31238067] [PMC:PMC6667285] Related Antibodies: LS-C100735.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).