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CAMK2A / CaMKII Alpha

calcium/calmodulin-dependent protein kinase II alpha

CAMK2A / CaMKII Alpha belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene Name: calcium/calmodulin-dependent protein kinase II alpha
Family/Subfamily: Protein Kinase , CAMK2
Synonyms: CAMK2A, AlphaCaMKII, CaM-kinase II alpha chain, CaMK-II subunit alpha, CAMKA, CaM kinase II alpha, CaMK II alpha, CaMK-II alpha subunit, CaMKIINalpha, CaM kinase II alpha subunit, CaM kinase II subunit alpha, CaMKII alpha, CaMKIIalpha, KIAA0968
Target Sequences: NM_015981 NP_057065.2 Q9UQM7

Publications (3)

1
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Cardin JA, Carln M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Nature. 2009 459:663-7. (IHC) [PubMed:19396156]
2
Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Dabrowska J, Rainnie DG. Neuroscience. 2010 171:721-33. (IHC-Fr; Rat) [Full Text Article] [PubMed:20849929] [PMC:PMC2987400]
3
Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder. Shanshan Zhu, Zachary A Cordner, Jiali Xiong, Chi-Tso Chiu, Arabiye Artola, Yanning Zuo, Andrew D Nelson, Tae-Yeon Kim, Natalya Zaika, Brian M Woolums, Evan J Hess, Xiaofang Wang, De-Maw Chuang, Mikhail M Pletnikov, Paul M Jenkins, Kellie L Tamashiro, Christopher A Ross. Proceedings of the National Academy of Sciences of the United States of America. 2017 September;114:10479-10484. [Full Text Article] [PubMed:28894008] [PMC:PMC5625892]

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ELISA Kits (14)
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CAMK2A / CaMKII Alpha (14)
Human (5)
Mouse (2)
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96-Well Microplate (1)
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No (14)
Cell Lysates (2)
Plasma (3)
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Tissue Homogenates (4)
CAMK2A / CaMKII Alpha ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
CAMK2A / CaMKII Alpha ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CAMK2A / CaMKII Alpha ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CAMK2A / CaMKII Alpha ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CAMK2A / CaMKII Alpha ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CAMK2A / CaMKII Alpha ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
CAMK2A / CaMKII Alpha ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
CAMK2A / CaMKII Alpha ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
CAMK2A / CaMKII Alpha ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
CAMK2A / CaMKII Alpha ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$854
CAMK2A / CaMKII Alpha ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
CAMK2A / CaMKII Alpha ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CAMK2A / CaMKII Alpha ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$893
CAMK2A / CaMKII Alpha ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$834
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).