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CAMK2A / CaMKII Alpha

calcium/calmodulin-dependent protein kinase II alpha

CAMK2A / CaMKII Alpha belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene Name: calcium/calmodulin-dependent protein kinase II alpha
Family/Subfamily: Protein Kinase , CAMK2
Synonyms: CAMK2A, AlphaCaMKII, CaM-kinase II alpha chain, CaMK-II subunit alpha, CAMKA, CaM kinase II alpha, CaMK II alpha, CaMK-II alpha subunit, CaMKIINalpha, CaM kinase II alpha subunit, CaM kinase II subunit alpha, CaMKII alpha, CaMKIIalpha, KIAA0968
Target Sequences: NM_015981 NP_057065.2 Q9UQM7

Publications (4)

1
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Cardin JA, Carln M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Nature. 2009 459:663-7. (IHC) [PubMed:19396156]
2
Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Dabrowska J, Rainnie DG. Neuroscience. 2010 171:721-33. (IHC-Fr; Rat) [Full Text Article] [PubMed:20849929] [PMC:PMC2987400]
3
Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder. Shanshan Zhu, Zachary A Cordner, Jiali Xiong, Chi-Tso Chiu, Arabiye Artola, Yanning Zuo, Andrew D Nelson, Tae-Yeon Kim, Natalya Zaika, Brian M Woolums, Evan J Hess, Xiaofang Wang, De-Maw Chuang, Mikhail M Pletnikov, Paul M Jenkins, Kellie L Tamashiro, Christopher A Ross. Proceedings of the National Academy of Sciences of the United States of America. 2017 September;114:10479-10484. [Full Text Article] [PubMed:28894008] [PMC:PMC5625892]
4
Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1. Federica Pilotto, Christopher Douthwaite, Rim Diab, XiaoQian Ye, Zahraa Al Qassab, Christoph Tietje, Meriem Mounassir, Adolfo Odriozola, Aishwarya Thapa, Ronald A M Buijsen, Sophie Lagache, Anne-Christine Uldry, Manfred Heller, Stefan Müller, Willeke M C van Roon-Mom, Benoît Zuber, Sabine Liebscher, Smita Saxena. Neuron. 2023 August;111:2523-2543.e10. [Full Text Article] [PubMed:37321222] [PMC:PMC10359637]
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CAMK2A / CaMKII Alpha Antibody - Anti-CAMK2A antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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Neuroscience
CAMK2A / CaMKII Alpha Goat anti-Human Polyclonal (aa455-468) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CAMK2A / CaMKII Alpha Antibody - Anti-CAMK2A antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Neuroscience
CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Dog, Rat, Orangutan, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
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CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal Antibody
Mouse, Bovine, Rat
ELISA, IF, IHC, IP, RIA, WB
Unconjugated
25 µg/$483; 100 µg/$688
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CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$890
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CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal (HRP) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$1,104
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CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal (Biotin) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$1,104
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CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal (FITC) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$1,104
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CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal (APC) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$1,104
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CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal (PE) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
PE Conjugated
100 µl/$1,104
CAMK2A / CaMKII Alpha ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CAMK2A / CaMKII Alpha Antibody - 1:100 staining human kindey carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (pThr286) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAMK2A / CaMKII Alpha Antibody - 1:100 staining human kindey carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (pThr305) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAMK2A / CaMKII Alpha Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAMK2A / CaMKII Alpha Antibody - 1:100 staining mouse intestine tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CAMK2A / CaMKII Alpha Mouse anti-Mouse Monoclonal (aa281-294) Antibody
Mouse, Rat
ELISA, ICC, IP, WB
Unconjugated
100 µl/$875
CAMK2A / CaMKII Alpha Antibody - Immunofluorescence of monoclonal antibody to CAMK2A on HeLa cell. [antibody concentration 10 ug/ml]
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CAMK2A / CaMKII Alpha Mouse anti-Human Monoclonal (2C4) Antibody
Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$423
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CAMK2A / CaMKII Alpha Mouse anti-Mouse Monoclonal (6G9) Antibody
Mouse, Bovine, Rat
IHC, RIA, WB
Unconjugated
100 µg/$531
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CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (aa446-478) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (aa446-478) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (aa446-478) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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CAMK2A / CaMKII Alpha Mouse anti-Mouse Monoclonal (aa281-294) (22B1) Antibody
Mouse, Rat
IF, WB
Unconjugated
100 µg/$531
CAMK2A / CaMKII Alpha Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with CAMK2A (C-term E370) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (aa344-371) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CAMK2A / CaMKII Alpha Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal (aa446-478) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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CAMK2A / CaMKII Alpha Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
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CAMK2A / CaMKII Alpha Mouse anti-Rat Monoclonal Antibody
Bovine, Rat
ELISA, IHC, WB
Unconjugated
100 µg/$884
Viewing 1-25 of 82 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).