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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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CALCOCO1 / CoCoa
calcium binding and coiled-coil domain 1
Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions.
| Gene Name: | calcium binding and coiled-coil domain 1 |
| Synonyms: | CALCOCO1, Calphoglin, PP13275, Sarcoma antigen NY-SAR-3, Cocoa, KIAA1536 |
| Target Sequences: | NM_020898 NP_065949.1 Q9P1Z2 |
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