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CACNA2D2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Family/Subfamily: Ion Channel , Calcium channel - alpha subunit 2 / delta
Synonyms: CACNA2D2, CACNA2D, Gene 26, KIAA0558, LUAC11.1, Alpha-2-delta-B, Alpha2delta-2, Ducky
Target Sequences: nm_006030 NP_006021.2 Q9NY47

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Products
Antibodies (19)
Primary (19)
CACNA2D2 (19)
Human (18)
Mouse (14)
Rat (4)
Bovine (3)
Chimpanzee (3)
Gibbon (3)
Orangutan (3)
Pig (3)
IHC (11)
IHC-Fr (1)
IHC-P (4)
WB (18)
Flo (2)
ELISA (11)
IF (1)
rabbit (18)
mouse (1)
Product Group
IHCPlus (1)
IgG (11)
IgG2a,k (1)
monoclonal mc (1)
polyclonal pc (18)
3A4 (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (11)
aa643-671 (7)
aa1030-1079 (4)
No (19)
CACNA2D2 Antibody - CACNA2D2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cerebellum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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CACNA2D2 Rabbit anti-Human Polyclonal (aa643-671) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CACNA2D2 Antibody - Anti-CACNA2D2 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CACNA2D2 Mouse anti-Human Monoclonal (3A4) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CACNA2D2 Antibody - CACNA2D2 antibody Western Blot of HCT15.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CACNA2D2 Rabbit anti-Human Polyclonal (aa1030-1079) Antibody
Human
WB
Unconjugated
100 µl/$424
CACNA2D2 Antibody - CACNA2D2 antibody Western Blot of HCT15.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CACNA2D2 Rabbit anti-Human Polyclonal (aa1030-1079) (HRP) Antibody
Mouse, Bovine, Pig, Orangutan, Gibbon, Human, Chimpanzee
WB
HRP Conjugated
100 µl/$469
CACNA2D2 Antibody - CACNA2D2 antibody Western Blot of HCT15.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CACNA2D2 Rabbit anti-Human Polyclonal (aa1030-1079) (Biotin) Antibody
Mouse, Bovine, Pig, Orangutan, Gibbon, Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
CACNA2D2 Antibody - CACNA2D2 antibody Western Blot of HCT15.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CACNA2D2 Rabbit anti-Human Polyclonal (aa1030-1079) (FITC) Antibody
Mouse, Bovine, Pig, Orangutan, Gibbon, Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
CACNA2D2 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer at dilution 1:100
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CACNA2D2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
CACNA2D2 Antibody - Western blot analysis of CACNA2D2 using anti-CACNA2D2 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: human MCF-7 whole cell lysate. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CACNA2D2 antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for CACNA2D2 at approximately 130KD. The expected band size for CACNA2D2 is at 130KD.
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CACNA2D2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, Flo, IHC-Fr, WB
Unconjugated
10 µg/$318; 100 µg/$470
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CACNA2D2 Rabbit anti-Human Polyclonal (aa643-671) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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CACNA2D2 Rabbit anti-Mouse Polyclonal (aa643-671) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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CACNA2D2 Rabbit anti-Mouse Polyclonal (aa643-671) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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CACNA2D2 Rabbit anti-Mouse Polyclonal (aa643-671) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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CACNA2D2 Rabbit anti-Mouse Polyclonal (aa643-671) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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CACNA2D2 Rabbit anti-Mouse Polyclonal (aa643-671) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
CACNA2D2 Antibody - Western blot testing of human MCF7 cell lysate with CACNA2D2 antibody at 0.5ug/ml. Predicted molecular weight ~130 kDa.
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CACNA2D2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$575
CACNA2D2 Antibody - Immunohistochemical analysis of CACNA2D2 staining in rat brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CACNA2D2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
CACNA2D2 Antibody - Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue  using CACNA2D2 Polyclonal Antibody at dilution of 1:45(×200)
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CACNA2D2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CACNA2D2 Antibody
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CACNA2D2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
CACNA2D2 Antibody - Western blot analysis of extracts of various cell lines, using CACNA2D2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 1s.
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CACNA2D2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
WB
Unconjugated
20 µl/$275; 100 µl/$389
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).