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Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Gene Name: | calcium channel, voltage-dependent, L type, alpha 1S subunit |
Family/Subfamily: | Ion Channel , Calcium channel - alpha subunit Cav1 |
Synonyms: | CACNA1S, Alpha 1S, Cav1.1, CACNL1A3, CACN1, CCHL1A3, DHPR alpha 1S, Dihydropyridine receptor, HOKPP1, HypoPP, MHS5, HOKPP, TTPP1, CACH1 |
Target Sequences: | NM_000069 AAA51902.1 Q13698 |
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