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CACNA1H / Cav3.2

calcium channel, voltage-dependent, T type, alpha 1H subunit

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Gene Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Family/Subfamily: Ion Channel , Calcium channel - alpha subunit Cav3
Synonyms: CACNA1H, Alpha 1h, Cav3.2, CACNA1HB, EIG6, MNCb-1209, ECA6
Target Sequences: NM_021098 NP_066921.2 O95180

Publications (1)

1
Glycosylation of CaV3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes. Sonja Lj Joksimovic, J Grayson Evans, William E McIntire, Peihan Orestes, Paula Q Barrett, Vesna Jevtovic-Todorovic, Slobodan M Todorovic. Frontiers in cellular neuroscience. 2021 January;14:605312. [Full Text Article] [PubMed:33384586] [PMC:PMC7770106] Related Antibodies: LS-C153507.

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CACNA1H / Cav3.2 ELISA Kit
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).