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Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
Gene Name: | calcium channel, voltage-dependent, R type, alpha 1E subunit |
Family/Subfamily: | Ion Channel , Calcium channel - alpha subunit Cav2 |
Synonyms: | CACNA1E, BII, Brain calcium channel II, Cav2.3, CACNL1A6, Alpha 1e, CACH6, Cchra1 |
Target Sequences: | NM_000721 NP_000712.2 Q15878 |
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