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CA4 / Carbonic Anhydrase IV
carbonic anhydrase IV
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport.
| Gene Name: | carbonic anhydrase IV |
| Synonyms: | CA4, Carbonate dehydratase IV, Carbonic dehydratase IV, CA-IV, CAIV, Carbonic anhydrase IV, Car4, RP17, Carbonic anhydrase 4 |
| Target Sequences: | NM_000717 NP_000708.1 P22748 |
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